Abstract

The management of and outlook for patients with acute leukemia is strikingly different than it was 10 years ago. The introduction and refinement of empirically based combination chemotherapy in the early 1960’s not only demonstrably improved the response and survival of acute leukemia victims, but equally stimulated basic scientists and clinicians alike to view this malady as an entity which could be cured within the foreseeable future. With this stimulus a remarkable amount of careful, and, often, inspired research has been conducted with the idea of better understanding and controlling this illness. In 1975, the task is not to stimulate interest in the pathogenesis and pathophysiology of leukemia, but to determine whether sufficient information is already available to consistently manage the disease, and, if so, how best to integrate current knowledge.

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