Abstract
Summary. The aim of this study was to investigate the level and the structure of antimicrobial resistance of Streptococcus pneumoniae in different regions of Russia. A total of 1,031 strains of S. pneumoniae from 20 centers of 15 cities of Central, North-Western, Southern, Far-Eastern, Privolzhsky, Ural, and Siberian Federal Districts were included in the study. Susceptibility to 13 antimicrobials was determined in according to MUC 4.2-1890.04 (ICA, Smolensk, Russia) and Clinical and Laboratory Standards Institute (CLSI, USA). Resistance to penicillin, amoxicillin, ceftriaxone, ceftidoren, ceftibuten, and cefixime did not exceed 11.7, 0.3, 4.6, 2.9, 14.5, and 8.7 %, respectively. Resistance rate was 6.4 % for erythromycin, 5.7 % for azithromycin, 9.0 % for clarithromycin, and 7.3 % for midecamycin. The high in vitro activity (97.4 %) against the strains of S. pneumoniae was found for levofloxacin. High resistance to tetracycline and co-trimoxazole was detected being 27.4 % and 21.5 %, respectively. Therefore, b-lactams demonstrated high activity against the strains of S. pneumoniae. Ceftriaxone and cefditoren had comparable activity that was higher than that for ceftibuten and cefixime. Low resistance rate of S. pneumoniae was found to macrolides and levofloxacin. High resistance to tetracycline and co-trimoxazole dictates the need to limit their use for treatment of pneumococcal infections.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
