Abstract
Personalized functional imaging identifies brain stimulation target for a patient with trauma-induced functional disruption
Highlights
The patient was a 21-year-old male snowboard athlete who sustained severe trauma during training that resulted in an intracranial venous sinus thrombosis, cerebellar hematoma, and obstructive hydrocephalus
On Jun 8th, 2020, treatment began with an efficient form of high-frequency transcranial magnetic stimulation (TMS) known as intermittent theta burst stimulation using a Magstim Rapid magnetic stimulator (Magstim, Whitland, U.K.) with a figure-ofeight coil placed over the left DMPFC (Fig. 1B)
We found remarkable improvements in his general cognitive functioning and mood, with 38.3e84.6% increases in testing scores (Fig. 1C and Tables S1 and S2)
Summary
The patient was a 21-year-old male snowboard athlete who sustained severe trauma during training that resulted in an intracranial venous sinus thrombosis, cerebellar hematoma, and obstructive hydrocephalus. To map the patient's functional network organization and assess the integrity of functional connectivity, we collected 24-min resting state fMRI data and parcellated the patient's cerebral cortex into 18 individual-specific functional networks (see supplementary methods) [4]. A functional abnormality map was generated (see supplementary methods) by comparing the patient's fMRI with 1000 healthy subjects' data.
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