PERSONALIZED APPROACH TO THE DIAGNOSIS OF CHILDREN WITH EXOGENOUS CONSTITUTIONAL OBESITY AGAINST THE BACKGROUND OF LEPTIN RESISTANCE

Abstract

Abstract: Despite the fact that modern society is relatively well informed about the problem of childhood obesity, as well as a lot of work is being done by WHO to eliminate it, leading experts in the field of endocrinology believe that not always due importance is attached to the identification of risk factors, often the diagnosis of "Obesity" is not made in a timely manner and, accordingly, measures are not taken to prevent the development and progression of obesity in children. Modern parents do not consider the excess body weight of the child a pathology. Up to 70% of obese children are monitored only after 6-10 years from the appearance of the first signs of the disease. And on the part of specialists, additional research methods in obese children, which include the assessment of the hormonal profile, are recommended by leading experts only if secondary obesity is suspected. In this approach, it is overlooked that excess body weight and an increase in adipocytes in volume contributes to the production of a giant amount of leptin, which provokes a condition such as leptin resistance. This pathological condition is the leading cause of exogenous constitutional obesity in children today. For these reasons, leptin resistance in children all over the world is not diagnosed in a timely manner and therapy has been carried out unsuccessfully for years without affecting the etiology of the disease. The diagnostic method developed by us, taking into account the clinical signs of the disease, combining at least 5 clinical signs of exogenous constitutional obesity and an increase in the compliance index, allows us to establish leptin resistance without determining the level of leptin.