Abstract
Alterations induced in the endometrium by IUDs and their mechanism of action, impeding pregnancy, have been widely discussed (Willson, Ledger & Andrios, 1965; Ledger, Virkar & Irvin, 1966; Batta & Chaudhury, 1968; Craig, 1969; DeBoer & Anderson, 1971; Warren & Hawk, 1971). Varying observations were reported on clinical material (Willson et al., 1965; Ober, Sobrero, Kurman & Gold, 1968; Sagiroglu, 1971) and diverse endometrial injuries were induced in animals (Corfman & Ritchart, 1967; Craig, 1967; Sudha, Chakravarti & Chaudhury, 1967; Moore & Bo, 1971). In the present study, the pathogenesis of lasting endometrial damage caused by long-term insertion of IUDs in experimental animals was investigated. `Intramedic' polyethylene tubes No. 100 (Clay-Adams) were inserted at laparotomy into the length of the uterine horns of female albino rats (local breed, Charles River strain), weighing 150 to 200 g each. The proximal end of the exposed horn was incised, the tube was introduced
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