Abstract
Background: Prolonged lactic acidosis (LA) correlates with severe cerebral injury in asphyxiated animal models. Few studies have evaluated LA and lactate clearance in neonates undergoing therapeutic hypothermia (TH) for hypoxicischemic encephalopathy (HIE). We hypothesize that delayed normalization of serum lactate during TH reflects a more severe cerebral injury. Objective: To determine whether degree of LA prior to initiation of TH, as well as serum lactate clearance and time to normalization of serum lactate level during TH, can …
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