Abstract
Effects of radiation in biological systems are quite interesting. Interaction of radiation to epigenetic mechanisms has been also demonstrated earlier. The aim of this review is to sketch a current scenario on radiation exposure/insults on the epigenetic mechanisms in mammalian cells. Evidence from the databases, mainly from Pubmed and Science Direct were considered. Findings suggest that radiation has a dose and time-dependent effect in our body. Cells and tissues from different sources have differential responses towards radiation insults. Although radiation has impacts on epigenetic modulation, but it has beneficial combinatorial effects with a number of epigenetic modalities. Radiation has both bad and good impacts on epigenetic mechanisms.
Highlights
Radiotherapy is one of effective modalities in cancer treatment
This review focuses radiation exposure/insults on epigenetic mechanisms in mammalian cells
Epigenetic modulation by radiation exposure/insults et al (1996) hyper-radiosensitivity is seen between 0.02 to 80 Gy in different mammalian cells, where ells irradiated by low-dose radiation (LDR)
Summary
Radiotherapy is one of effective modalities in cancer treatment. Ionizing radiation (IR) exposure is essential to improve radiotherapy in this case. Radiation exposure induces a multitude of biological effects, including cancer and degenerative diseases (Boerma et al, 2016; Kutanzi et al, 2016). Epigenetics is the study of heritable changes in gene expression that are not associated with alterations in the primary DNA sequence.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
