Persea Americana’s Extract Could Offer Effective Treatment for Amyotrophic Lateral Sclerosis: A Hypothesis

Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a rare neuro-degenerative disease characterized by the degeneration of upper and lower motor neurons in the central and peripheral nervous systems. Several pathological conditions, including neuroinflammation, oxidative stress, and mitochondrial dysfunction, contribute to the degeneration of motor neurons. Despite extensive research, no current drug therapies have proven effective in treating ALS. Purpose: This study explores the therapeutic potential of Persea americana (PA) Mill, commonly known as avocado, in the treatment of ALS. Methods: The review draws on pre-clinical and clinical studies that have demonstrated the neuroprotective effects of PA extracts (PAE) in diseases such as Alzheimer's and Parkinson's, highlighting the potential mechanisms that may be relevant to ALS. Results: Although no studies have directly investigated the effects of PA on ALS, the bioactive compounds in PA have shown promising results in mitigating neurodegenerative processes through their diverse biological activities. Conclusion: Based on existing evidence from related neurodegenerative conditions and the mechanisms involved in ALS pathology, it is hypothesized that PA extracts may offer a novel therapeutic avenue for ALS. Further research is required to validate the efficacy of PAE in managing ALS symptoms and slowing disease progression.