Peroxisome proliferator acivated receptor δ (PPAR δ) activation enhances the development of cryopreserved embryos

Abstract

Prostacyclin analog, iloprost, enhances the hatching, implantation, and live birth of mouse embryos (Huang et al, 2003, 2004). The enhancements are likely mediated via PPARδ, a nuclear receptor (Kang et al, 2011). L165041, a PPARδ ligand, mimics the effects of iloprost on fresh mouse embryos (Huang et al, 2007a, b). In this report we determine the effect of L165041 on the development of post-thaw embryos.