Permeation of Indomethacin through Skin Using Nanonized Alaptide

Aneta Cernikova,Josef Jampilek,Jiri Dohnal

doi:10.5599/admet.3.4.247

Aneta Cernikova, Josef Jampilek + Show 1 more

Open Access

https://doi.org/10.5599/admet.3.4.247

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Journal: ADMET & DMPK	Publication Date: Dec 30, 2015
Citations: 4	License type: cc-by

Affiliation: University of Veterinary Sciences Brno

Abstract

Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is an original Czech compound; in this paper it is used as an excipient. The investigation deals with the affection of the permeation of indomethacin through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicle of propylene glycol/water (1:1) using nanonized alaptide as a potential transdermal permeation enhancer. Alaptide was applied in ratio 1:10 (w/w) related to the amount of indomethacin. Nanonized alaptide showed an excellent rapid onset of enhancement effect, already at the 30 th minute after application, when the permeated amount of indomethacin was 5-fold more than in the formulation without alaptide. The enhancement ratio of nanonized alaptide was 5.6, which indicates that alaptide modifies skin structure, which results in significantly enhanced permeation at long-term application.

Highlights

Transdermal administration of drugs can be considered as an alternative to conventional pharmaceutical dosage forms
The enhancement ratio of nanonized alaptide was 5.6, which indicates that alaptide modifies skin structure, which results in significantly enhanced permeation at long-term application
The permeation of indomethacin through the skin without and with nanonized alaptide (NALA) was tested from the donor vehicle of propylene glycol/water (1:1)

Summary

Introduction

Transdermal administration of drugs can be considered as an alternative to conventional pharmaceutical dosage forms. The investigation deals with the affection of the permeation of indomethacin through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicle of propylene glycol/water (1:1) using nanonized alaptide as a potential transdermal permeation enhancer. This follow-up paper to the previous contributions [18−22] is aimed at the investigation of the effect of nanonized alaptide as a potential CPE on the permeation of indomethacin substance through the skin.

Results

Conclusion