Abstract
The activity of acetylcholinesterase and lactate dehydrogenase was examined in subcellular fractions of the cerebellum from normal adult rats and adult rats receiving one dose of X-rays (600 R) to the head at 6 days of age. Acetylcholinesterase activity was significantly elevated in the irradiated animals, the effect being most marked in the crude mitochondrial and cytoplasmic fractions. Similarly, lactate dehydrogenase activity was slightly elevated in the cytoplasmic fraction. The results are discussed in comparison with available histological data on radiation effects on developing cerebellum. It is suggested that the increased acetylcholinesterase concentration after early irradiation represents a relative sparing of cholinergic neurons.
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