Abstract
Intraplantar administration of serotonin 5-HT 3 receptor antagonists ICS 205–930 and MDL 72222 (1–100 μg; 50 μl) produced dose-related analgesia against formalin-induced acute- and Freunds adjuvant-induced chronic-inflammatory pain in rats. 5-HT 3 receptor antagonists had greater effect in the chronic pain test that in the acute paradigm. In both tests, ICS 205–930 was more potent than MDL 72222. These data further support the involvement of peripheral 5-HT 3 sites in inflammatory pain, and suggest the utility of selective 5-HT 3 receptor antagonists as peripheral analgesics.
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