Abstract
Background Inflammatory bowel disease (IBD) is a collective term, generally referring to ulcerative colitis (UC) and Crohn’s disease (CD). Distinguishing between the sub-diagnoses of IBD as well as differential diagnoses such as irritable bowel syndrome (IBS) poses a challenge to the gastroenterologist because of the large overlap in clinical features. Making a correct diagnosis is important because treatment alternatives differ greatly between the two entities. Still, many patients are mis-diagnosed every year, and thus, there is need for developing improved diagnostic methods. In this study, we have used flow cytometry to investigate the expression of 20 chemokine receptors on the CD3+, CD14+ and CD19+ peripheral blood leukocyte populations in patients with UC, CD and IBS.
Highlights
Inflammatory bowel disease (IBD) is a collective term, generally referring to ulcerative colitis (UC) and Crohn’s disease (CD)
Between UC and CD, 12 parameters were able to distinguish the diagnoses with CXCR5 on CD14+ monocytes accounting for the largest difference in expression
Our results show that chemokine receptor expression profiles on peripheral blood leukocyte subsets differ significantly between patients diagnosed with UC, CD and irritable bowel syndrome (IBS)
Summary
Peripheral blood leukocytes express differential chemokine receptor profiles in irritable bowel syndrome, Crohn’s disease and ulcerative colitis. From 7th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk aan Zee, the Netherlands. 28-30 November 2012
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