Peripheral androgen blockade in men with castrate-sensitive biochemical recurrent prostate cancer.

Abstract

The aim of the study was to evaluate the feasibility of utilizing peripheral androgen blockade in men with biochemical recurrent castrate-sensitive prostate cancer. A registration study to track outcomes of men with biochemical recurrent castrate-sensitive prostate cancer treated with peripheral androgen blockade utilizing concomitant administration of finasteride and bicalutamide. Men were on intermittent peripheral blockade for a median 20.2months, continuous peripheral blockade for a median 6.8months, intermittent triple dose peripheral androgen blockade for a median 10.7months, and continuous triple dose peripheral androgen blockade for 4.4months before failing therapy. Six men (21%) had additional therapies during treatment that included metastasis-directed therapy (5/37, 14%), systemic Lu-177 (2/37, 5%), and salvage RT (1/37, 3%). The median time to progression, which includes time from initiation through all therapies to the initiation of ADT, was 37.6months (IQR 20-74.7). From the start of PAB, median time to castrate resistance was 49.8months (IQR 40.9-NR). After starting ADT, median time to castrate resistance was 8.8months (IQR 4.6-17.7). Our data support the exploration of PAB as a treatment option in carefully selected patients who present with biochemical recurrence after failure of definitive local therapy for prostate cancer.