Abstract
1. A single i.p. dose of taurine (25 mg/mouse) given to mice 3 hr before an i.p. injection of morphine (0.1 mg/mouse) decreased the analgesic response of the animals to morphine. 2. Neither a lower dose of taurine nor the same dose of another amino acid was effective. 3. The analgesic response to morphine was also reduced by inclusion of taurine in the drinking water. 4. The results of the present study indicate that peripherally administered taurine antagonized morphine-induced analgesia, similar to a previous report that taurine administered centrally, diminished the analgesic response to a centrally injected opioid peptide.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call