Abstract
Plain Language SummaryPeriostin is a matricellular protein expressed in multiple tissues of the cardiovascular system, including the heart. Elevated serum concentrations of periostin have been documented in conditions such as heart failure, coronary artery disease, and stroke. Individuals with end-stage kidney disease (ESKD) face a significantly heightened risk of cardiovascular diseases. However, there is a dearth of clinical studies elucidating the prognostic significance of systemic periostin with respect to all-cause mortality in ESKD patients undergoing hemodialysis. Consequently, we conducted a prospective observational study on a cohort of ESKD patients, tracking their outcomes over a span of 5 years.In summary, our investigation establishes that serum periostin serves as an independent risk factor for all-cause mortality among male patients undergoing hemodialysis for chronic kidney disease. Notably, the impact of serum periostin concentrations on all-cause mortality is observed solely in male patients, with no corresponding effect in female patients. We provide a comprehensive discussion elucidating the reasons underlying this pronounced gender dependence.
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