Abstract
Objecive: to study and compare the time course of hemostatic changes in patients with acute coronary syndrome (ACS) and chronic coronary heart disease (CCHD) undergoing surgical myocardial revascularization. Subjects and methods. Eleven hemostatic parameters were determined at 3 study stages (before, within 24 hours after surgery and before hospital discharge) in 20 patients with CCHD and 23 with ACS. Results: The study demonstrated that there was a preponderance of a higher blood tendency to intravascular thrombogenesis in all the patients at all the stages of the study; however, the degree of disorders and the cases of their occurrence in the CCHD and ACS groups varied. Conclusion: There was an increased blood tendency to coagulation in all the patients despite the therapy performed. In the CCHD group, hemostatic disorders were, as before, more pronounced than those in the ACS group. These facts suggest that the reserve functional capacities of the hemostatic system become normal only a significant amount of time after elimination of thrombogenic change-causing agents.
Highlights
Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow 1 O
Eleven hemostatic parameters were determined at 3 study stages in 20 patients with chronic coronary heart disease (CCHD) and 23 with acute coronary syndrome (ACS)
The study demon strated that there was a preponderance of a higher blood tendency to intravascular thrombogenesis in all the patients at all the stages of the study; the degree of disorders and the cases of their occurrence in the CCHD and ACS groups varied
Summary
Цель исследования — изучить и сравнить динамику показателей системы гемостаза у больных острым коронар ным синдромом (ОКС) и хронической ишемической болезнью сердца (ХИБС), перенесших хирургическую реваскуляризацию миокарда в условиях ИК. У 20 больных хронической ишемической болезнью сердца (ХИБС) и 23 больных острым коронарным синдромом (ОКС), перенесших хирургическую реваскуляризацию миокарда в условиях искусственного кровообращения определяли 11 показателей системы гемостаза на 3 х этапах исследования (перед операцией, первые сутки после операции и перед выпиской из стационара). Objecive: to study and compare the time course of hemostatic changes in patients with acute coronary syndrome (ACS) and chronic coronary heart disease (CCHD) undergoing surgical myocardial revascularization. Изучить и сравнить динамику показателей системы гемостаза у больных c хронической ишемичес кой болезнью сердца (ХИБС) и острым коронарным синдромом (ОКС), перенесших хирургическую ревас куляризацию миокарда в условиях искусственного кро вообращения (ИК)
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