Abstract
Corresponding author: Dr Dragan SUBOTIC, MD, PhD, FCCP Institute for lung Diseases, Belgrade, Visegradska 26/20 Serbia E-mail: vilusi@yubc.net; Tel: +38 11 1361 5559 Since the latest revision of the TNM system reclassified T3N0 tumours into the IIB stage, N2 lesions became the major determinant of the IIIA stage. Concerning the minority of patients with T3N1 tumours in this stage, their prognosis depends on characteristic of T3 tumours: localised chest wall invasion is associated with more favourable prognosis compared to those T3 tumours that either directly invade the mediastinum, or have the proximal propagation < 2 cm from the central carina. The significance of preoperative confirmation of metastases in mediastinal lymph nodes was recognized long ago, based on survival differences depending on whether N2 lesions were confirmed preoperatively or not (Tab 1).
Published Version
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