Perioperative changes of peripheral monocyte cells in patients with atherosclerosis obliteration

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Objective To evaluate the perioperative changes of peripheral monocyte cells in patients with atherosclerosis obliteration. Methods The study was a retrospective, single-center study that enrolled 76 patients with lower limb arteriosclerosis obliterans from May 2014 to May 2017, receiving endovascular treatment in our hospital. Patients were divided into control group (Fontaine stage Ⅱ with intermittent claudication group) or critical limb ischemia (CLI) group (Fontaine stage Ⅲ-Ⅳ with rest pain, ulceration or necrosis) , who were successfully treated with endovascular surgery. The observed values included gender, age, smoking index, diabetes, hypertension, peripheral monocyte count (on admission, 24 h post-operation, 72 h postoperation, 2 weeks to 2 months after surgery) . Results Patients with CLI (n=32) had elevated preoperative peripheral monocyte counts compared with control patients (n=44) [ (0.850±0.183) ×109/L vs (0.478±0.091) ×109/L, P<0.001], which all decreased after endovascular treatment. The prevalence of type 2 diabetes for the difference in other observed values. Multivariable logistic regression analysis demonstrated that CLI group was significantly higher than the control group (24/32 vs 20/44, P=0.009) . There was no peripheral monocyte count was the only independent predictor for the severity of limb ischemia in patients with lower extremity atherosclerotic occlusion (P<0.001) . Conclusions The peripheral monocyte count of the patients with CLI was significantly increased before treatment, and decreased after tissue perfusion improved. We believed that the peripheral monocyte may be a clinically useful maker in the diagnosis and treatment for the patients with atherosclerosis obliterans, and the postoperative secondary mobilization may be the key to revascularization and angiogenesis. Key words: Ischemia; Monocyte; Atherosclerosis obliterans