Abstract
NONSTEROIDAL antiinflammatory drugs (NSAIDs) inhibit prostaglandin synthesis. Because renal blood flow depends on prostaglandin, particularly when circulating blood volume is decreased, a recommendation has been made that NSAIDs be withheld before surgery because of the risk of renal dysfunction. 1 However, there has been no report of perioperative renal dysfunction attributable to preoperative administration of NSAIDs, and a recent review has endorsed preoperative administration of NSAIDs for minor outpatient procedures and a combined multimodality drug therapy including NSAIDs after surgery. 2 The authors report a case of perioperative acute renal failure after lumbar discectomy in a young patient who was taking ibuprofen preoperatively.
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