Abstract

Periodontal disease is a major public health issue, and various periodontal therapies have been performed to regenerate periodontal tissues. The periodontium is a complex structure composed of specialized tissues that support the teeth, and most periodontal surgeries are invasive procedures, including a resection of the gingiva or the alveolar bone. The periodontal wound healing process is slightly different from cutaneous wound healing and is similar to fetal healing, being almost scar-free. The aim of this review article is to provide an overview of periodontal wound healing and discuss various surgical and pharmaceutical approaches to achieve stable wound healing and improve the treatment outcomes. In addition, detrimental and limiting factors that induce a compromised prognosis are discussed, along with the perspective and future direction for successful periodontal tissue regeneration.

Highlights

  • The periodontium acts as a supporting apparatus for the teeth and is a comple

  • The objective of this review is to provide an overview of periodontal wound healing and discuss the complications and factors influencing the healing process and therapeutics for improving periodontal wound healing

  • Swelling is defined as the enlargement of a body part as a result of inflammation or filling with tissue fluids and is considered to be a normal postoperative reaction until it interferes with wound healing [31]

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Summary

A Narrative Review

Citation: Cho, Y.-D.; Kim, K.-H.; Lee, Y.-M.; Ku, Y.; Seol, Y.-J. Periodontal Wound Healing and Tissue Regeneration: A Narrative Review. Pharmaceuticals 2021, 14, x. Citation: Cho, Y.-D.; Kim, K.-H.; Lee, Academic Editor: Yayoi Kawano, Y.-M.; Ku, Y.; Seol, Y.-J. Periodontal HanRegeneration:

Introduction
Normal Wound Healing
Attenuated
Differential Angiogenesis Pattern
Periodontal Treatment and Wound Healing
Tooth Extraction
Resective Periodontal Surgery
Regenerative Periodontal Surgery
Complications after Periodontal Treatment
Postoperative Infection
Bleeding
Swelling
Scar Formation
Factors Affecting Periodontal Wound Healing
Smoking
Biopharmaceutical Approaches
Collagen
Blood-Derived Products
Periodontal Dressing Materials
Devices to Improve Wound Healing
Method
Hyperbaric Oxygen
Perspective and Future Directions

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