Periodontal Gel For The Targeted Drug Delivery In The Periodontal Cavity For Management Of Periodontitis And Gingivitis

Abstract

When medications are taken orally or through another route into the systemic circulation, their blood concentration steadily rises andpeaks (C max) after a few hours. Based on the medication's physicochemical makeup, the drug's pharmacokinetics (ADME). Amaintenance dose must be given when the medication level is expected to be reduced or close to the efficacy threshold after achievingthe peak plasma concentration (C max) in blood [1]. We can now distribute medications to the systemic circulation in a controlled andprecise manner for longer pharmacological action, minimize the frequency of dose and unpleasant effects, improve patient compliance,and give the desired impact. Since several processes occur after a medication is administered at the application site and before it reachesthe target location in CDDS, its concentration in the blood is frequently affected by metabolism and excretion, making it difficult tonotice the desired impact. This issue can be solved by injecting the medications right into the affected area, allowing a lower dose toproduce the desired effect. Local drug delivery systems are more effective since they are less expensive, more stable, less toxic,biocompatible, and biodegradable. The proper management of a patient with periodontitis and gingivitis, the utilization of periodontalpockets as a site for the application of medication, the design of an appropriate dose form, and its potential benefits are the main topicsof this review. A unique technique for treating diseases like periodontitis and gingivitis could be useful in a more effective treatmentsince the microorganisms in periodontal pockets could seriously destroy periodontal tissues.