Abstract
In the form of the literature review we shows the concept of the treatment of high-risk hypertensive patients, who have been taking ACE inhibitors which application is the most advanced approach from the perspective of evidence-based cardiology. One of the most studied drugs is perindopril. The article deals with the data on the special properties of perindopril molecules, as well as on the possibilities of using perindopril and indapamide combination, as well as on usage of indapamide and amlodipine for the realization of protective mechanism. At the conclusion of the article we offered the differentiated approach to the usage of different drugs containing perindopril for different indications.
Highlights
In the form of the literature review we shows the concept of the treatment of high-risk hypertensive patients, who have been taking ACE inhibitors which application is the most advanced approach from the perspective of evidence-based cardiology
At the conclusion of the article we offered the differentiated approach to the usage of different drugs containing perindopril for different indications
Что на фоне комбинированной терапии периндоприлом и антагониста кальция (АК) отмечалась меньшая частота достижения первичной конечной точки по сравнению с пациентами, получавшими только АК или находившимися без антигипертензивной терапии (АГТ) [16]
Summary
Через 4 года наблюдения оказалось, что частота первичной конечной точки (сердечная сосудистая смерть, нефатальный ИМ, остановка сердца с успешной реанимацией) на 20% реже отмечалась в группе периндоприла по сравнению с группой плацебо. Целью исследования ADVANCE, в которое были включены 11 140 пациентов, была оценка влияния терапии комбинации периндоприл 4–8 мг + индапамид 2,5 мг на сердечно-сосудистые события у пациентов с сахарным диабетом типа 2.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have