Perinatal complications associated with Prader-Willi syndrome (PWS) – comparison to the general population and among the different genetic subtypes.

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Background: Prader-Willi Syndrome (PWS) is caused by lack of expression of genes on the paternal chromosome 15 (15q11.2 - 15q13 region). There is an evolving phenotype for patients with either a deletion, Uniparental Disomy (UPD) or Imprinting Center Defect (ICD). Patients present prenatally with decreased fetal movements, higher pregnancy complications and hypotonia, dysmorphism and feeding difficulties in postnatal period. Objectives: 1) Compare the clinical features of PWS in pregnancy and early neonatal period to the general population. 2) Compare the clinical features of …