Abstract
BackgroundThe variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines.MethodsA total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5’UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR. Serum leptin, adiponectin, resistin and ghrelin levels were studied by ELISA method in both groups and their link with perilipin polymorphisms were analyzed.ResultsSerum leptin level was found significantly high in obese adolescents. Other adipokine levels were similar in both groups. The incidence of PLIN 1, PLIN 4, PLIN 5’UTR-1234 C > G and PLIN 10171 A/T minor and major alleles was similar in both groups. PLIN 6 T/T allele was determined significantly high in obese adolescents compared to that of control group. No correlation was detected between perilipin polymorphism and serum levels of adipokines.ConclusionThe PLIN 6 polymorphism of the perilipin gene may influence the risk of the obesity during adolescence.Trial registrationRetrospectively registered.
Highlights
The variations in perilipin gene (PLIN) were previously associated with obesity
After adipose tissue was understood to have a role in the metabolism sex steroids and leptin was discovered, this conventional thought has changed completely
The idea that white adipose tissue is not a simple fat storage and it can have a part in the energy balance of the body has formed a ground
Summary
The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines. White adipose tissue has been thought to be a simple fat storage. The idea that white adipose tissue is not a simple fat storage and it can have a part in the energy balance of the body has formed a ground. Thereafter, over 50 types of cytokines and other molecules released from this tissue have been described and commenced to be referred to as adipokine. These adipokines are linked with endocrine, paracrine and other mechanisms and they play a role in many physiological and pathological events.
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