Abstract
I n the use of any root canal filling material, we believe it is necessary to determine the tissue response in the periapical area to each of the material’s ingredients. Metallic oxides have frequently been added to root canal materials. Zinc oxide is a basic ingredient in root canal sealers. Titanium dioxide is a component of AH-26i and N,$ cements. Lead oxide is an ingredient of Robins and Cortisomollj root canal cements, and aluminum oxide has recently been tested as a filler for improvement of the quality of zinc oxide-eugenol cement.lb4 The present study was undertaken to investigate periapical tissue reaction to zinc, titanium, lead, and aluminum oxides. These powders were applied as a paste by adding inert vehicles in the root canal of the rat molar.
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