Abstract
In this work, the metal and semiconducting nanoparticles (AgNPs, ZnONPs and AgZnONPs) were phyto-synthesized using aqueous vegetal extracts from: Caryophyllus aromaticus L. (cloves) and Citrus reticulata L. (mandarin) peels. The morphological, structural, compositional, optical and biological properties (antibacterial activity, and cytotoxicity) of the prepared composites were investigated. The most effective sample proved to be AgZnONPs, derived from cloves, with a minimum inhibitory concentration (MIC) value of 0.11 mg/mL and a minimum bactericidal concentration (MBC) value of 2.68 mg/mL. All the other three composites inhibited bacterial growth at a concentration between 0.25 mg/mL and 0.37 mg/mL, with a bactericidal concentration between 3 mg/mL and 4 mg/mL. The obtained composites presented biocidal activity against Staphylococcus aureus, and biocompatibility (on human fibroblast BJ cells) and did not damage the human red blood cells. Additionally, an important result is that the presence of silver in composite materials improved the bactericidal action of these nanomaterials against the most common nosocomial pathogen, Staphylococcus aureus.
Highlights
An important result is that the presence of silver in composite materials improved the bactericidal action of these nanomaterials against the most common nosocomial pathogen, Staphylococcus aureus
The design of new antibacterial systems is of real interest today, in the context of nosocomial infections producing many victims, as bacteria become increasingly resistant to antibiotics
The X-ray diffraction (XRD) patterns obtained on the synthesized samples: AgZnO-CUI, AgZnO-MAND, ZnO-CUI, ZnO-MAND, Ag-CUI and
Summary
The design of new antibacterial systems is of real interest today, in the context of nosocomial infections producing many victims, as bacteria become increasingly resistant to antibiotics. Nano-scaled inorganic compounds like silver and zinc oxide exhibit antibacterial activity at a very low dose due to their high surface area to volume ratio which confer them interesting features [2]. Silver nanoparticles (AgNPs) have been used for a long time as antimicrobials, due to their interesting physical, chemical and biological properties, making them suitable for applications in industry and biomedical fields [3]. Due to non-penetrating property to human skin, AgNPs have been used as safe preservatives in different cosmetic products [4]. ZnO is known for its antimicrobial activity from immemorial times [5], being used during the regime of Pharaohs (in 2000 BC) in many ointments for disease, treatment of injuries and boils. ZnO is used in cosmetics, in sunscreen lotions, optoelectronic devices, solar cells, photo-catalysis [7]
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