Abstract
SummaryBackgroundWe aimed to evaluate and improve the accuracy of the ultrasound scan in estimating gestational age in late pregnancy (ie, after 24 weeks' gestation) in low-income and middle-income countries (LMICs), where access to ultrasound in the first half of pregnancy is rare and where intrauterine growth restriction is prevalent.MethodsThis prospective, population-based, cohort study was done in three LMICs (Bangladesh, Pakistan, and Tanzania) participating in the WHO Alliance for Maternal and Newborn Health Improvement study. Women carrying a live singleton fetus dated by crown-rump length (CRL) measurements between 8+0–14+6 weeks of gestation, who were willing to return for two additional ultrasound scans, and who planned on delivering in the study area were enrolled in the study. Participants underwent ultrasonography at 24+0–29+6 weeks and at 30+0–36+6 weeks' gestation. Birthweights were measured within 72 h of birth, and the proportions of infants who had a small-for-gestational-age birthweight (ie, a birthweight <10% of the standard birthweight for the infant's gestational age and sex according to the INTERGROWTH-21st project newborn baby reference standards) and appropriate-for-gestational-age birthweights were ascertained. Estimation of gestational age by standard fetal biometry measurements in addition to transcerebellar diameter (TCD) measurements was compared with gold-standard CRL measurements by use of Bland-Altman plots to calculate the mean difference and 95% limits of agreement. Statistical modelling was done to develop new gestational age prediction formulas for third trimester ultrasonography in LMICs.FindingsBetween Feb 7, 2015, and Jan 9, 2017, 1947 women were enrolled in the study. 1387 pregnant women had an ultrasound scan at 24+0–29+6 weeks of gestation and 1403 had an ultrasound scan between 30+0–36+6 weeks of gestation. Of the 1379 unique infants whose birthweights were available, 981 (71·1%) infants were born with an appropriate-for-gestational-age birthweight and 398 (28·9%) infants were born with a small-for-gestational-age birthweight. The accuracy of late pregnancy ultrasound biometry using existing formulas to estimate gestational age in LMICs was similar to that in high-income settings. With standard dating formulas, late pregnancy ultrasound at 24+0–29+6 weeks' gestation was accurate to within approximately plus or minus 2 weeks of the gold-standard CRL measurement of gestational age, and late pregnancy ultrasound was accurate to within ±3 weeks of the CRL measurement at 30+0–36+6 weeks' gestation. In infants who were ultimately born small for gestational age, individual parameters systematically underestimated gestational age, apart from TCD, which showed minimal bias. By use of a novel parsimonious model formula that combined TCD with femur length, gestational age at the 24+0 −29+6-week ultrasound scan was estimated to within ±10·5 days of the CRL measurement and estimated to within ±15·1 days of the CRL measurement at the 30+0–36+6-week ultrasound scan. Similar results were observed in infants who were small-for-gestational-age.InterpretationIncorporation of TCD and the use of new formulas in late pregnancy ultrasound scans could improve the accuracy of gestational age estimation in both appropriate-for-gestational-age and small-for-gestational-age infants in LMICs. Given the high rates of small-for-gestational-age infants in LMICs, these results might be especially relevant. Validation of this new formula in other LMIC populations is needed to establish whether the accuracy of the late pregnancy ultrasound can be narrowed to within approximately 2 weeks.FundingBill & Melinda Gates Foundation.
Highlights
Pregnancy dating is an essential component of antenatal care
The first trimester ultrasound is considered to be the gold-standard method for estimating gestational age in high-income settings,[5] but ultrasound early in gestation might not be routinely available in low-income and middle-income countries (LMICs)
Ultrasound biometry becomes less accurate for estimating gestational age, given the emergence of natural variation in fetal size and the possibility of pathological growth restriction
Summary
Accurate estimation of gestational age is needed to optimise provision of obstetric interventions and delivery location for preterm births, and it is a prerequisite to identify and manage fetal growth abnormalities. In low-income and middle-income countries (LMICs), where the burden of preterm birth and intrauterine growth restriction is highest,[1,2] assessing gestational age accurately can be challenging because of many factors. The first trimester ultrasound is considered to be the gold-standard method for estimating gestational age in high-income settings,[5] but ultrasound early in gestation might not be routinely available in LMICs. In addition, pregnant women in LMICs might not present for antenatal care in early pregnancy. Ultrasound biometry becomes less accurate for estimating gestational age, given the emergence of natural variation in fetal size and the possibility of pathological growth restriction. In LMICs, where 19·3% of infants are born small-for-gestational-age,[6] the assumption that fetal size predicts gestational age might not be valid
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.