Performance of high-frequency ultrasound in the evaluation of skin involvement in cutaneous chronic graft-versus-host disease: A preliminary report

Abstract

To the Editor: Cutaneous chronic graft-versus-host disease (cGVHD) is the most frequent manifestation of cGVHD, developing a few months/years after allogeneic hematopoietic stem cell transplants. Cutaneous cGVHD can be clinically classified as sclerotic or nonsclerotic. Sclerotic manifestations are commonly observed during the late phase of cGVHD, inducing significant morbidity, functional impairment, and prolonged immunosuppressive therapy.1 An objective, noninvasive, and early detection of skin sclerodermatous changes is essential for preventing the irreversible sequela and for monitoring treatment response.