Abstract
4645 Background: Prostate cells released into expressed prostatic secretions (EPS) during prostatic massage are easily collected and analyzed. Prior work has shown EPS to perform well as a noninvasive test to predict prostate biopsy outcomes. We evaluate the utility of EPS biomarkers to predict surgical pathology outcomes in patients undergoing radical prostatectomy. Methods: We collected EPS specimens in a blinded prospective study from 138 men undergoing radical prostatectomy for prostate cancer. Specimens were obtained in the operating room under general anesthesia before commencing with radical prostatectomy. Specimens were analyzed for expression of GADH, PC3, Type III and VI TMPRSS2:ERG gene fusions using quantitative PCR. Their characteristic performance for predicting extracapsular extension (ECE) and Gleason sum on surgical pathology specimens was evaluated. These were compared to pre-biopsy PSA, biopsy Gleason sum and digital rectal exam (DRE) findings as predictors of surgical pathology outcome...
Published Version
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