Performance of a seizure warning algorithm based on the dynamics of intracranial EEG

Abstract

During the past decade, several studies have demonstrated experimental evidence that temporal lobe seizures are preceded by changes in dynamical properties (both spatial and temporal) of electroencephalograph (EEG) signals. In this study, we evaluate a method, based on chaos theory and global optimization techniques, for detecting pre-seizure states by monitoring the spatio-temporal changes in the dynamics of the EEG signal. The method employs the estimation of the short-term maximum Lyapunov exponent (STL max), a measure of the order (chaoticity) of a dynamical system, to quantify the EEG dynamics per electrode site. A global optimization technique is also employed to identify critical electrode sites that are involved in the seizure development. An important practical result of this study was the development of an automated seizure warning system (ASWS). The algorithm was tested in continuous, long-term EEG recordings, 3–14 days in duration, obtained from 10 patients with refractory temporal lobe epilepsy. In this analysis, for each patient, the EEG recordings were divided into training and testing datasets. We used the first portion of the data that contained half of the seizures to train the algorithm, where the algorithm achieved a sensitivity of 76.12% with an overall false prediction rate of 0.17 h −1. With the optimal parameter setting obtained from the training phase, the prediction performance of the algorithm during the testing phase achieved a sensitivity of 68.75% with an overall false prediction rate of 0.15 h −1. The results of this study confirm our previous observations from a smaller number of patients: the development of automated seizure warning devices for diagnostic and therapeutic purposes is feasible and practically useful.