Abstract

X-ray and gamma-ray imaging are technologies with several applications in nuclear medicine, homeland security, and high-energy astrophysics. However, it is generally difficult to realize simultaneous wide-band imaging ranging from a few tens of keV to MeV because different interactions between photons and the detector material occur, depending on the photon energies. For instance, photoabsorption occurs below 100 keV, whereas Compton scattering dominates above a few hundreds of keV. Moreover, radioactive sources generally emit both X-ray and gamma-ray photons. In this study, we develop a “hybrid” Compton camera that can simultaneously achieve X-ray and gamma-ray imaging by combining features of “Compton” and “pinhole” cameras in a single detector system. Similar to conventional Compton cameras, the detector consists of two layers of scintillator arrays with the forward layer acting as a scatterer for high-energy photons (> 200 keV) and an active pinhole for low-energy photons (< 200 keV). The experimental results on the performance of the hybrid camera were consistent with those from the Geant4 simulation. We simultaneously imaged ^{241}Am (60 keV) and ^{137}Cs (662 keV) in the same field of view, achieving an angular resolution of 10^circ (FWHM) for both sources. In addition, imaging of ^{211}At was conducted for the application in future nuclear medicine, particularly radionuclide therapy. The initial demonstrative images of the ^{211}At phantom were reconstructed using the pinhole mode (using 79 keV) and Compton mode (using 570 keV), exhibiting significant similarities in source-position localization. We also verified that a mouse injected with 1 MBq of ^{211}At can be imaged via pinhole-mode measurement in an hour.

Highlights

  • X-ray and gamma-ray imaging are technologies with several applications in nuclear medicine, homeland security, and high-energy astrophysics

  • Two common techniques—single photon emission computed tomography (SPECT) and positron emission tomography (PET)—play important roles in the diagnosis. They image a specific energy range of either X-rays or gamma rays; SPECT can image gamma rays with energies less than 300 keV with the use of the collimator, whereas PET can image positron emitters that emit 511-keV gamma rays. These lead to a limited number of radioactive tracers that can be imaged only with current SPECT and PET scanners

  • They succeeded in realizing the triple gamma (i.e., PET/Compton) imaging of 44Sc, which emits 511 keV and 1,157 keV gamma rays; the application to imaging SPECT tracer remains to be researched in the future

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Summary

Introduction

X-ray and gamma-ray imaging are technologies with several applications in nuclear medicine, homeland security, and high-energy astrophysics. Yoshida et al (2020) proposed whole gamma imaging (WGI) wherein a conventional PET scanner is converted by inserting an additional scatterer to create a Compton c­ amera[10] They succeeded in realizing the triple gamma (i.e., PET/Compton) imaging of 44Sc, which emits 511 keV and 1,157 keV gamma rays; the application to imaging SPECT tracer remains to be researched in the future. In this context, the simultaneous capture of SPECT and PET images has been reported using a Compton camera consisting of Si/CdTe semiconductors, which is, limited both in terms of detection efficiency and angular ­resolution[11,12,13]. We initially investigated the capability of our hybrid camera system with a simple phantom of 211 At and conducted mouse imaging

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