Abstract
AbstractThe construction and performance characteristics of an ion selective membrane electrode for labetalol drugs in protonated form, based on their ion‐pair complexes with sodium tetraphenylborate (TPB‐Na+) incorporated in a poly(vinyl chloride) matrix, are described. The Labetalol‐H+ selective electrode can be used practically for the determination of the pharmaceutical compound by direct potentiometry. The potentiometric sensor exhibits near‐Nernstian response from 10−2 M to about 10−5 M, with a slope of 55 mV/decade of concentration and detection limit of 4.46 × 10−6 M. The influence of changing the membrane characteristics, pH, and temperature of the test solution on the electrode potential are studied. The response time varies from a few seconds to several minutes, depending on labetalol concentration. The selectivity of the electrode for Lab‐H+ toward primary, secondary, tertiary, and quaternary amines is investigated. Determination of Lab‐H+ in pharmaceutical tablets is performed using the proposed membrane electrode. No interference from any excipients in the tablets was observed.
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