Abstract
Aim. To assess the comparative 30-day effectiveness of percutaneous coronary intervention (PCI) with bioresorbable vascular scaffold (BVS) versus minimally invasive direct coronary artery bypass (MIDCAB) for left anterior descending coronary artery disease.Methods. 130 patients with significant (≥70%) LAD disease were recruited in the study. Patients were randomized either to PCI with BVS (n = 65) or MIDCAB (n = 65). The groups of patients were comparable in baseline demographic, clinical and angiographic parameters. The endpoints included adverse cardiovascular events (all-cause mortality, myocardial infarction, stroke, target vessel revascularization) and scaffold thrombosis and were measured on day 30 after the indexed intervention.Results. At 30-day follow-up, there were no significant differences in the incidence of the adverse cardiovascular events between the study groups (0% MIDCAB vs. 3.1% PCI, р = 0.151), myocardial infarction (0% vs. 3.1%, p = 0.151), target vessel revascularization (0% vs. 1.5%, p = 0.32) and scaffold (graft) thrombosis (0% vs. 1.5%, p = 0.32).Conclusion. PCI with BVS and MIDCAB in patients with stable coronary artery disease and isolated left anterior descending lesions demonstrated comparable outcomes at 30-days follow-up.
Highlights
Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Сосновый бульвар, 6, Кемерово, Российская Федерация, 650002
At 30-day follow-up, there were no significant differences in the incidence of the adverse cardiovascular events between the study groups (0% minimally invasive direct coronary artery bypass (MIDCAB) vs. 3.1% percutaneous coronary intervention (PCI), р = 0.151), myocardial infarction (0% vs. 3.1%, p = 0.151), target vessel revascularization (0% vs. 1.5%, p = 0.32) and scaffold thrombosis (0% vs. 1.5%, p = 0.32)
Percutaneous coronary intervention with bioresorbable vascular scaffold versus minimally invasive off-pump bypass surgery: 30-days follow up
Summary
Впервые на основе данных, полученных в исследовании, были сопоставлены два малоинвазивных метода реваскуляризации миокарда с применением биодеградируемого сосудистого каркаса у пациентов со стабильной ИБС и изолированным поражением передней нисходящей артерии. Реализация задач исследования позволила получить новые знания о двух перспективных малоинвазивных методах реваскуляризации на основании широкого спектра объективных данных и внедрить их в клиническую практику. Внедрение новых подходов к реваскуляризации миокарда, в основу которых положен принцип малоинвазивности, позволит оптимизировать результаты лечения пациентов с ИБС, послеоперационных осложнений, повторных госпитализаций, инвалидизации и смертности
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