Abstract
A pharmacokinetic model was developed to test certain concepts regarding the percutaneous absorption of indomethacin from topical ointment bases. Both the drug from the ointment bases and absorption from the skin followed first-order kinetics, with the exception of the initial period (lag time). The ointment bases selected for study were solution-type and suspension-type ointment bases. Indomethacin was most effectively absorbed from absorption ointment bases. The effect of additives on the percutaneous absorption was also investigated using absorption ointment bases. The optimal effect with additives in the ointment bases was finally attained with the addition of 0.5% urea.
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