Perceptive of block co polymers as potential delivering system of synthesized pyridine and pyrimidine derivatives: Spectroscopic and computational approach

Abstract

In this work, a pyridine containing Schiff-base, 1-((anthracen-10-yl)methylene)-2-(pyridin-2-yl)hydrazine (AP) and a pyrimidine containing Schiff-base 2-(2-(Anthracen-9-ylmethylene) hydrazinyl)-4, 6-dimethyl pyrimidine (ANHP) have been synthesized and characterized by IR, NMR, HRMS and different spectroscopic methods. Two different tri block co polymers (P-123 and F-127) have been used as delivering system of this poor water soluble drug molecule AP and ANHP which are the main investigation of this work. To find out which one is the better delivering systems of AP and ANHP, spectroscopic studies have been carried out in P-123 and F-127 polymeric media. From the interactions of AP and ANHP with P-123 and F-127 polymers individually, binding constant values have been determined. The drug delivering efficiency of block co polymers has been investigated by using different spectroscopic techniques like absorbance, fluorescence, DLS and time resolved fluorescence measurements. All these experimental results indicate that P-123 is the better AP and ANHP delivering system than F-127 polymer. In addition, the structural properties like bond length, bond angles etc. of AP have been calculated by using density functional theory (DFT).