Abstract
Background: DM is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormal insulin secretion, insulin action, or both. Symptoms that are complained of in diabetes mellitus sufferers are polydipsia, polyuria, polyphagia, weight loss, and tingling sensation. The oral glucose tolerance test is a test used to diagnose DM when the blood glucose level is less firm, during pregnancy, or to screen for DM or TGT. Leptin is a hormone produced by fat cells that regulate fat storage in the body and adjusts hunger to energy expenditure. Objective: to find out more about the role of leptin on TTGO in people with Type 2 diabetes. Methods: using literature studies from both national and international journals to increase knowledge and understanding of the topics discussed by summarizing the discussion topics and comparing the results presented in the article. Results: Leptin on TTGO examination in individuals with impaired glucose tolerance had a greater chance of becoming diabetes mellitus if there was no intervention in their lifestyle. Conclusion: Leptin plays a role in checking TTGO in people with Type 2 diabetes
Highlights
DM is a group of metabolic diseases characterized by hyperglycemia
that occurs due to abnormal insulin secretion
a hormone produced by fat cells that regulates fat storage in the body
Summary
Poliuri, polifagia, penurunan berat badan, dan kesemutan. Tes toleransi glukosa oral merupakan tes yang digunakan untuk menegakkan diagnosis DM saat level glukosa darah kurang tegas, saat kehamilan, atau untuk skrining DM maupun TGT. Leptin merupakan hormon yang diproduksi oleh sel lemak yang meregulasi penimbunan lemak di tubuh dan menyesuaikan antara rasa lapar dengan pengeluaran energi.Tujuan: mengetahui lebih lanjut tentang peran leptin terhadap. TTGO pada penderita DM Tipe 2 Metode: Menggunakan studi literatur dari jurnal baik nasional maupun internasional untuk menambah pengetahuan dan pemahaman mengenai topik yang dibahas dengan cara meringkas topik pembahasan dan membandingkan hasil yang disajikan dalam artikel. Hasil: Leptin terhadap pemeriksaan TTGO pada individu dengan toleransi glukosa terganggu berpeluang lebih besar menjadi diabetes melitus apabila tidak ada intervensi pada gaya hidupnya. Kesimpulan: Leptin berperan terhadap pemeriksan TTGO pada penderita DM Tipe 2
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