Abstract
Tumor necrosis factor-α (TNF-α) and platelet-activating factor (PAF) have been implicated in the pathogenesis of human immunodeficiency virus (HIV)-associated encephalopathy. The effects of pentoxifylline on brain PAF levels were examined in mice infected with the LP-BM5 murine leukemia virus (MuLV). Seven weeks after viral inoculation, significant increases in serum TNF-α and brain PAF levels were observed. One week of treatment with pentoxifylline initiated 6 weeks postinfection significantly reduced both serum TNF-α and brain PAF levels. A significant positive correlation was observed between the levels of these substances ( r=0.62; P<0.01). This study demonstrates that pentoxifylline treatment was effective in decreasing the levels of TNF-α in the serum and PAF levels in the brain of mice infected with the LP-BM5 MuLV.
Published Version
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