Pentacyclic triterpenes with nitric oxide inhibitory activity from Potentilla chinensis

Abstract

Three new ursane-type triterpenes (1–3) and twenty-one known triterpenoids (4–24) were isolated from the methanolic extract of the whole plants of Potentilla chinensis. Their structures were elucidated by extensive spectroscopic analysis of 1D and 2D NMR (HSQC, HMBC, COSY and ROESY) and HRESIMS data. The bioassay screening revealed the inhibitory effects on nitric oxide production of compounds 2, 5, 7, 9, 10, and 13–24 in LPS-induced RAW264.7 macrophages.