Penile Intraepithelial Neoplasia (Erythroplasia of Queyrat, Bowen’s Disease)

Abstract

Penile intraepithelial neoplasia (PIN) is in situ squamous cell carcinoma of the male genitalia with no invasion into the dermis or lymphovascular system. Penile intraepithelial neoplasia has three variants: erythroplasia of Queyrat, Bowen’s disease (Bowen disease), and bowenoid papulosis. The distinction between Bowen’s disease of the penis and erythroplasia of Queyrat is historical. Bowen’s disease of the penis is in situ squamous cell carcinoma (SCC) of genital hair-bearing skin (the penile shaft or scrotum) (Fig. 50.1). Erythroplasia of Queyrat is in situ SCC of the glans penis or of the mucosal aspect of the foreskin in uncircumcised men (Figs. 50.2, 50.3, 50.4, and 50.5). The term erythroplasia of Queyrat could be abandoned, as it is a subset of male genital Bowen’s disease and both are encompassed within penile intraepithelial neoplasia [1]. Bowenoid papulosis exhibits different biologic behaviour from penile Bowen’s disease and erythroplasia of Queyrat and is discussed separately in Chap. 51.