753 PENILE INTRAEPITHELIAL NEOPLASIA; INCIDENCE IN THE NETHERLANDS

Abstract

You have accessJournal of UrologyPenis/Testis/Urethra: Benign & Malignant Disease II1 Apr 2012753 PENILE INTRAEPITHELIAL NEOPLASIA; INCIDENCE IN THE NETHERLANDS Robert Hoekstra, Evelien Trip, Fiebo Ten Kate, Simon Horenblas, and Tycho Lock Robert HoekstraRobert Hoekstra Utrecht, Netherlands More articles by this author , Evelien TripEvelien Trip Utrecht, Netherlands More articles by this author , Fiebo Ten KateFiebo Ten Kate Utrecht, Netherlands More articles by this author , Simon HorenblasSimon Horenblas Amsterdam, Netherlands More articles by this author , and Tycho LockTycho Lock Utrecht, Netherlands More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.839AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Penile intraepithelial neoplasia (PIN) is rarely diagnosed and considered as a premalignant condition, preceding an invasive penile cancer. Currently, the incidence of penile cancer tends to increase in the Netherlands; unclear is if this also applies for PIN. METHODS Data from patients diagnosed with a premalignant penile lesion in the Netherlands between January 1998 and December 2007 were collected from the unique nationwide histopathology registry (PALGA), this database is covering all pathology results of inhabitants in the Netherlands. The results from biopsies, circumcisions and partial or total penectomy specimens with premalignant penile lesions were evaluated. The premalignant lesions included were erythroplasia of Queyrat, Bowen's disease, bowenoid papulosis, mild, moderate and severe dysplasia and carcinoma in situ of the penis. The terminology used in the pathological reports was translated to PIN. The grading was made in analogy with the grading of vulvar premalignant lesions. Patients with a previous malignancy were excluded. When a penile malignancy was found within three months after a premalignant penile lesion was diagnosed, it was considered as primary penile carcinoma and these patients were excluded. In the pathology reports HPV status, location on the penis and the time-interval to malignant transformation were retrieved. RESULTS The PALGA database enrolled 658 patients with possible premalignant penile lesions between 1998-2007. After screening of these reports, 278 cases were eliminated because of exclusion criteria. Severe premalignant lesions (graded as PIN III) were found in 254 patients (67%), moderate PIN (PIN II) in 84 patients (22%), and mild PIN (PIN I) in 42 patients (11%). Most lesions were located on the prepuce (45%), followed by glans (38%) and shaft (3%). Median age of patients with PIN was 57 years; 51 years for PIN I and 60 years for PIN III. HPV-status was known in only 28 patients, in 11 (39%) HPV tests were negative and in 17 (61%) was tested positive. In 26 patients progression to malignant disease occurred (2% for PIN I versus 7% for PIN III). CONCLUSIONS PIN is a condition that is only rarely diagnosed, with an incidence in the Netherlands of 0.4-0.6 per 100,000 men. After a median follow up of 52 months (IQR 23-85) progression to malignancy was found in 7% of patients with PIN III. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e308 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Robert Hoekstra Utrecht, Netherlands More articles by this author Evelien Trip Utrecht, Netherlands More articles by this author Fiebo Ten Kate Utrecht, Netherlands More articles by this author Simon Horenblas Amsterdam, Netherlands More articles by this author Tycho Lock Utrecht, Netherlands More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...