Penile anthropometry in adolescents and adults systemic lupus erythematosus

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Results SLE patients had a lower median penis length and circumference [8(7.5-10) vs. 10(8-13) cm, p=0.0001; 8(710) vs. 10(7-11) cm, p=0.001; respectively], lower median testicular volume by right and left Prader [15(10-25) vs. 20(12-25) ml, p=0.003; 15(10-25) vs. 20(12-25) ml, p=0.006; respectively], higher median of FSH [5.8(2.125) vs. 3.3(1.9-9) IU/l, p=0.002] and lower morning total testosterone levels (28% vs. 0%, p=0.009) compared to controls. In spite of that, erectile dysfunction was not observed in patients or controls. Analyses of lupus patients revealed that the median penis circumference was lower in patients with disease onset before first ejaculation compared to those that began after first ejaculation [7.8(7-10) vs. 9.0(7.5-10) cm, p=0.026]. No differences were observed in the median penile anthropometry regarding sexual dysfunction (p=0.610), lower total testosterone levels (p=0.662), oligo/azoospermia (p=0.705), SLEDAI ≥ 4 (p=0.562), SLICC/ACR Damage Index ≥ 1 (p=0.478), prednisone cumulative dose (p=0.789) and intravenous cyclophosphamide therapy (p=0.754). Klinefelter’s syndrome (46XY/47XXY) was diagnosed in one (4%) SLE patient with decreased penile size whereas Y-chromosomal microdelections was absent in all of them.