Abstract
Three new dihydroisocoumarin derivatives, penicisimpins A⿿C (1⿿3), were isolated and identified from Penicillium simplicissimum MA-332, a fungus derived from the rhizosphere of the marine mangrove plant Bruguiera sexangula var. rhynchopetala. Their structures and absolute configurations were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment. Compounds 1⿿3 exhibited brine shrimp (Artemia salina) lethality as well as broad-spectrum antimicrobial activities.
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