Abstract
Monohaptenic DNCP-hexamethylenediamine derivatives carrying benzoyl or phenylacetyl groups as auxiliary structures elicit cutaneous anaphylactoid reactions in guinea pigs passively sensitized with anti-DNCP antiserum. An analogous compound with benzylpenicilloyl as auxiliary group is a markedly better elicitor and evokes apparently standard PCA. This implies that the thiazolidine moiety of benzylpenicilloyl is a better auxiliary structure than the benzyl side-chain and may endow penicillin derivatives with the capacity to act as monovalent elicitors of anaphylaxis. This was confirmed by the finding that the ε-aminocaproate of N 6-DNP-aminopenicillanic acid is an elicitor of anaphylactoid reactions in guinea pigs passively sensitized against DNP.
Published Version
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