Abstract
Abstract Of 160 hospitalized children who were thought to be allergic to penicillin, only 17 had positive immunologic tests. Of these, 16 had positive skin tests and only 10 had significant titers of hemagglutinating antibodies. Three children had acute, explosive reactions, 4 had accelerated reactions, and 11 had late-onset reactions. In the 143 children with negative immunological tests, the diagnosis of penicillin allergy was often questionable on clinical grounds alone. Whatever the clinical features, negative tests have helped to establish the safety of subsequent penicillin treatment for many of these children.
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