PENGARUH PEMBERIAN SALEP EKSTRAK ETANOL DAUN PILADANG(Solenostemonscutellarioides(L). Codd) SELAMA 15 HARI SECARA TOPIKAL TERHADAP AKTIVITAS PENYEMBUHAN LUKA EKSISI PADA TIKUS PUTIH JANTAN

Abstract

ABSTRACTA study has been conducted on the effect of ethanolic extract of piladang leaf (Solenostemon scutellarioides (L.) Codd) topically for 15 days on excision wound healing in male white rats. This study consisted of 5 groups of each group consisting of 3 rats, ie group I as control (Vaselin Flavum), Group II as comparator (Betadine® ointment), group III, IV, and V were the group given test preparation topical with an ointment concentration of 2%, 4% and 8% extract. The experimental animal was injured, then the initial wound was measured after it was applied to the back of the mouse 2 times a day given at 8 am and 4 pm for 15 days. On the 15th day, parameters such as percentage of wound healing and hydroxyproline measurement were performed, while epithelial time was performed every day until epithelial cell was formed. The results of data analysis using one way varian (ANOVA) showed that ethanol extract of pyuridic leaf can heal wound continued duncan test (SPSS 16.0) showed that there were significant differences between groups on wound healing parameters, wound healing percentage and hydroxyproline determination (p <0, 05), so it can be concluded that the preparation of leaf pyramid extract with 8% concentration more effective to give effect in wound healing.