Abstract
Patients withdiabetes mellitus(DM) continues to grow becauseprosperityandpeople's lifestyles.Treatment of diabetesoften useinjectionsof insulinandoralantidiabeticdrugs. Thetreatmenthas no side effects. Therefore, it isnecessary to findeffective drugsusing plantsthatred betelleaf(Piper crocatumRuiz&Pav.). Red betel leafcontains flavonoidswhichare antioxidants. This study aimsto determine the effectand dose ofextractof redbetel leaf(Piper crocatumRuiz&Pav.) The mosteffectiveagainstbloodglucosein mice(Mus musculusL.) maleinducedsucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.
Highlights
Diabetes melitus (DM) sering dikenal dengan penyakit gula atau kencing manis
The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice
B. Saran Berdasarkan hasil penelitian ini terlihat bahwa perlu dilakukan peningkatan dosis dan lama pemberian sukrosa dan ekstrak daun sirih merah (Piper crocatum Ruiz & Pav.) untuk melihat perbedaan yang lebih jelas pada masing-masing perlakuan yang diberikan, serta dapat dimanfaatkan sebagai obat alternatif yang menurunkan glukosa darah bagi penderita penyakit diabetes melitus
Summary
Diabetes melitus (DM) sering dikenal dengan penyakit gula atau kencing manis. Menurut World Health Organisation (WHO) (2015) DM adalah penyakit kronis yang terjadiketika pankreas tidak cukup menghasilkan insulinatau ketika tubuh tidak dapat secara efektif menggunakan insulin yang dihasilkan. Resistensi tersebut seperti timbulnya hipoglikemia, mual, rasa tidak enak di perutdan anoreksia.Oleh karena itu,banyak penderita yang berusaha mengendalikan kadar glukosa darahnya dengan cara tradisional menggunakan bahan alam seperti tanaman obat yang efek sampingnya relatif rendah dan harganya murah (Widowati dkk, 1997). Tanaman obat yang dapatmenurunkan kadar gula darah diantaranya yaitu sirih merah (Piper crocatum Ruiz & Pav.). Berdasarkan latar belakang ini dilakukan penelitian tentang “Pengaruh Ekstrak Daun Sirih Merah (Piper crocatum Ruiz & Pav.)terhadap Glukosa Darah Mencit (Mus musculus L.) Jantan yang Diinduksi Sukrosa”. Penelitian ini dilakukan dengan memberikan perlakuan ekstrak daun sirih merah (Piper crocatum Ruiz & Pav.) pada mencit (Mus musculus L.) jantan dengan dosis yang berbeda dan diamati kadar guloksa darahnya
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