Abstract
Citrinin is a sort of mycotoxin which caused mycotoxicosis. Citrinin is produced by Penicillium citrinum mold that can contaminate sort of food especially damaged beans.  Citrinin is known as nephrotoxic as well as hepatotoxic mycotoxin and caused hepatocite structure damage. This research was done: 1) to know the effect of citrinin to hepatocite structure damage; 2) to know the effect of citrinin dose difference to the value of the hepatocyte structure damage; 3) to know the effect of citrinin to the value of hepatocyte structure damage on three zones of hepar lobulus. The samples of this research were male mice (Mus musculus) var. BALB-C  at the age of three months. The experiment group of  mice was orally administered with citrinin in three doses, i.e: dose-1: 1 mg/kg BW; dose-2: 1,75 mg/kg BW; dose-3: 2,5 mg/kg BW. Hepatocyte structure damage is observed on centrilobular zone, midzone, and perifer zone. The hepatocyte structure damage examination is done by histopathologycal andultra structural examination by electron microscope.
Highlights
Citrinin is a sort of mycotoxin which caused mycotoxicosis
Citrinin is produced by Penicillium citrinum mold
The experiment group of mice was orally administered with citrinin in three doses
Summary
Data hasil penelitian mengenai pengaruh paparan citrinin dengan beberapa macam dosis terhadap kerusakan struktur hepatosit mencit pada 3 zona lobulus hepar seperti nampak pada Ringkasan Sidik Ragam pada Tabel 1. Berdasarkan Hasil analisis data dapat diketahui bahwa ada pengaruh beberapa macam dosis paparan citrinin terhadap kerusakan struktur hepatosit mencit, dan ada pengaruh paparan citrinin terhadap kerusakan struktur hepatosit pada ketiga zone lobulus hepar serta ada pengaruh interaksi dosis paparan citrinin dan zone lobulus hepar terhadap tingkat kerusakan srtuktur hepatosit mencit, hal ini dapat dilihat pada F hit > F tab 0,1% yang menunjukkan adanya pengaruh yang signifikans pada taraf 0,1%. Selanjutnya untuk mengetahui perbedaan pengaruh macam dosis paparan citrinin terhadap kerusakan struktur hepatosit mencit dan perbedaan pengaruh paparan citrinin terhadap kerusakan struktur hepatosit pada ketiga zona lobulus hepar, maka dilakukan uji lanjut BNJ 1% seperti nampak pada Tabel 2
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