Abstract
Germ cell tumors historically have been considered to be a single nosologic category comprising tumors with different histologic manifestations and different degrees of malignancy and arising at different sites of origin. Only in the last decade has the biologic heterogeneity of germ cell tumors been recognized and addressed. Therapy tailored for the many biologically distinct subsets of germ cell tumors has yet to be defined. Because many categories exclusively involve children, this challenge has been assumed by pediatric oncologists, resulting in the multi-institutional and multinational cooperative studies currently in progress. Current protocols utilize regimens that have been effective in adult germ cell tumors. The probability that the biologically unique pediatric subsets may be best treated by other regimens awaits future protocols.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call