Peculiarities remodeling the venous bed in the testis at postresection arterial hypertension in small blood circulation

Abstract

Morphological methods examined the venous bad testis of 45 laboratory white male rats, which were divided into 3 groups. The 1 group included 15 intact animals, 2 – 20 rats with pulmonary arterial hypertension and compensated cor pulmonale, 3 – 10 animals with pulmonary arterial hypertension and decompensated cor pulmonale. Hypertension in the small circulatory system and cor pulmonale was modeled by performing right-sided pulmonectomy in animals. It was found that the diameter of the capillary venules of the testis with compensated cor pulmonale was statistically (p<0.01) significantly increased by 4.5 %, and the diameter of venules - by 2.3 % (p<0.05), the external diameter of the venous vessels was statistically significant (p<0.05) increased by 3.1%, and internal – by 2.8 % (p<0.05). The height of endothelial cells of the venous vessels, the diameters of their nuclei in conditions of compensated cor pulmonale did not change significantly. The nuclear-cytoplasmic relations in endothelial cells were unchanged, which testified to the stability of cellular structural homeostasis. Studies and results show that the investigated morphometric parameters of venous vessels in decompensated cor pulmonale changed more pronounced. The diameter of the capillary venules in these experimental conditions increased by 19.1 % (p<0.001), the diameter of the venules – by 22.2 % (p<0.001), the outer diameter of the venous vessels increased by 18.5 % (p<0.001), and inner diameter by 22.3 % (p<0.001). The revealed remodeling of venous vessels resulted in thinning of their walls. At decompensation of the cor pulmonale, the height of the endothelial cells of the venous vessels of the testis decreased by 5.8 % (p<0.01), the diameters of the nuclei of these cells – by 2.8 % (p<0.01). Nuclear-cytoplasmic ratios changed by 6.4 % (p<0.001), indicating a marked disruption of structural cellular homeostasis. The relative volume of damaged endothelial cells of the venous testicular vessels in decompensated cor pulmonale increased in 17.5- times (p<0.001), which could lead to endothelial dysfunction and affect the degree of remodeling venous vessels of the testis. The data obtained indicate that postresection arterial hypertension in the small circle of circulation leads to pronounced structural changes in the venous bad in the testis, which significantly impairs the drainage of venous blood from the specified organ, worsens its trophic supply and plays an important role in its pathomorphogenesis. The most pronounced degree of remodeling of venous vessels was found in decompensated of the cor pulmonale.